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Pathology Practice MCQs

Browse 15,526 high-yield clinical questions in Pathology. Includes detailed explanations, options, and topic tags.

#12860 Organ Transplant / Graft

A 1-year-old girl with an inborn error of metabolism resulting in a lysosomal storage disease receives a hematopoietic stem cell transplant intended to replace her macrophage population. The gene of interest has a "marker" small nucleotide polymorphism within a non-coding intron of the affected gene in which an A (patient gene) is substituted for a G (donor gene). She does quite well for the first 3 weeks. She tests positive for the missing enzyme, her previously abnormally enlarged organs begin to diminish in size, and assay of peripheral blood lymphocytes reveals increasing numbers of cells with the G polymorphism. However, the attending physicians are now concerned because repeated genetic testing reveals a progressive increase in lymphocytes with the A nucleotide polymorphism. Which of the following is the best explanation for this finding?

#12890 Osteology

A 27-year-old man develops acute pain and swelling of the left knee 5 days after an episode of urethritis. On physical examination, the left knee is swollen, warm, and tender to the touch. No other joints are affected. Laboratory examination of fluid aspirated from the left knee joint shows numerous neutrophils. A Gram stain of the fluid shows with gram-negative intracellular diplococci. No crystals are seen. Which of the following infectious agents is most likely responsible for his condition?

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