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Pathology Practice MCQs

Browse 15,526 high-yield clinical questions in Pathology. Includes detailed explanations, options, and topic tags.

#11757 Central Nervous System

A 12-year-old boy develops fever, accompanied by occasional headaches, malaise, fatigue, and nausea a month after being bitten by a dog. One day later, he experiences episodes of rigidity, hallucinations, breath-holding, and difficulty swallowing because of uncontrollable oral secretions. Dr. Louis Pasteur is consulted. He writes: "The death of this child appearing to be inevitable, I decided, not without lively and sore anxiety, as may well be believed, to try ....... the method which I had found constantly successful with dogs. Consequently, 60 hours after the bites was inoculated under a fold of skin with half a syringeful of the spinal cord of a rabbit. In the following days, fresh inoculations were made. I thus made 13 inoculations." The boy survives. Which of the following histologic findings in the brain of the dog is most likely to be present?

#11769 Immunity

A 12-year-old boy has had multiple recurrent infections for the past 10 years, including Pneumocystis jiroveci pneumonia, Streptococcus pneumoniae otitis media, and Pseudomonas aeruginosa urinary tract infection. On physical examination, he has a temperature of 38.5deg C and pharyngeal erythema with exudate. Laboratory studies show hemoglobin, 9.1 g/ dL; hematocrit, 27.6%; platelet count, 130,900/mm3; and WBC count, 3440/mm3 with 47% segmented neutrophils, 3% bands, 40% lymphocytes, and 10% monocytes. Serum immunoglobulin levels show very low IgG, very high IgM, and undetectable IgA. A peripheral blood smear shows nucleated RBCs. Which of the following immunologic defects is most likely to produce this disease?

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