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Pathology General d8c3f7ff

True statement regarding Hirschsprung's disease?

A
Giant ganglia are present
B
Mucosa is involved and show foldings
C
Manometry excludes the disease
D
Rectal biopsy is contraindicated in infants
High-Yield Explanation
Ans. is 'c' i.e., Manometry excludes the diagnosis o Anorectal manometry is a useful screening procedure for the diagnosis of Hirschsprung's disease. A normal response in course of manometric evaluation precludes diagnosis of Hirschsprung's disease. o However the confirmation of diagnosis in case of Hirschsprung's disease is done by rectal biopsy.

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