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Pathology Practice MCQs

Browse 15,526 high-yield clinical questions in Pathology. Includes detailed explanations, options, and topic tags.

#1020 Environment & Nutritional Pathology

A 27-year-old, previously healthy man suddenly collapses at a party where both legal and illicit drugs are being used. En route to the hospital, he requires resuscitation with defibrillation to establish a normal cardiac rhythm. On physical examination, his temperature is 40deg C; respirations, 30/ min; heart rate, 110/min; and blood pressure, 175/90 mm Hg. He has dilated pupils, a perforated nasal septum, and a prominent callus on the right thumb. CT scan of the head shows an acute right frontal lobe hemorrhage. Which of the following substances is most likely responsible for these findings?

#1037 Central Nervous System

An 86-year-old man has become progressively unable to live independently for the past 10 years, and he now requires assistance with bathing, dressing, toileting, feeding, and transfers in and out of chairs and bed. On physical examination, he has no motor or sensory deficits. He cannot give the current date or state where he is. Six months later, he suddenly becomes comatose and dies. At autopsy, there is a large superficial left parietal lobe hemorrhage. Histologic examination of the brain shows numerous neocortical neuritic plaques and neurofibrillary tangles. The peripheral cerebral arteries and the core of each plaque stain positively with Congo red. Which of the following mechanisms is most likely responsible for his disease?

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