Antinuclear antibody specific for SLE is
High-Yield Explanation
Systemic lupus erythematosus (SLE) is a multisystem autoimmunedisease of protean manifestations and variableclinical behavior. Clinically, it is an unpredictable, remittingand relapsing disease of acute or insidious onset thatmay involve viually any organ in the body; however, itaffects principally the skin, kidneys, serosal membranes,joints, and hea.Antibodies to doublestranded DNA (dsDNA) and the so-called Smith (Sm) antigen can be detected by ELISA or multiplex flow methods and are specific for SLE.Robbins Basic pathology,9th edition,pg no.127