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General Medicine General cc26c11c

Biopsy of a persistent exophytic area on the vulva of a 60 year old woman demonstrates a squamous epithelial lesion. No koilocytes are seen. The lesions show papillary projections composed of disordered, squamous epithelium with well differentiated cells. The basement membrane at the dermal-epidermal junction is focally disrupted by squamous cell groups extending deep into the dermis. Which of the following diagnoses is most accurate?

A
Condyloma acuminatum
B
Extramammary Paget's disease
C
Vulvar intraepithelial neoplasia
D
Vulvar squamous cell carcinoma

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