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Pathology Practice MCQs

Browse 15,526 high-yield clinical questions in Pathology. Includes detailed explanations, options, and topic tags.

#9501 Central Nervous System

A 50-year-old man presents with a "staggering" gait and "lightning pain" in his hands and legs. His past medical history is significant for an aortic aneurysm and aortic insufficiency. Neurologic examination reveals impaired senses of vibration, as well as touch and pain in the lower extremities. The patient subsequently dies of pneumonia. Autopsy discloses obliterative endarteritis of meningeal blood vessels and atrophy of the posterior columns of the spinal cord. What is the appropriate diagnosis?

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#9506 Infectious Disease

A 52-year-old man has a fever and cough productive of thick, gelatinous sputum that worsens over 4 days. On physical examination, his temperature is 38.2deg C. On auscultation of the chest, diffuse crackles are heard at the right lung base. Laboratory studies show WBC count, 13,240/mm3 with 71% segmented neutrophils, 8% bands, 15% lymphocytes, and 6% monocytes. A sputum gram stain shows gram-negative bacilli with mucoid capsules. His condition improves after a course of gentamicin therapy. Which of the following complications of this infection is he most likely to develop?

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#9508 Head & Neck

A 42-year-old man has had a constant bad taste in his mouth for the past month. On physical examination there are white fluffy patches on the sides of his tongue. These cannot be scraped off. A biopsy is taken and on microscopic examination shows squamous epithelial hyperkeratosis, parakeratosis, and koilocytosis. Immunohistochemical staining for Epstein- Barr virus (EBV) is positive. Which of the following is the most likely risk factor for his oral lesions?

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#9526 Immunity

A 14-month-old child has had multiple infections since birth, including pneumonia with Pseudomonas aeruginosa, adenovirus, and Aspergillus fumigatus; diarrhea with Isospora belli; otitis media with Haemophilus influenzae; and urinary tract infection with Candida albicans. Laboratory studies show hemoglobin, 13.2 g/dL; hematocrit, 39.7%; platelet count, 239,100/mm3; and WBC count, 3450/mm3 with 85% segmented neutrophils, 6% bands, 2% lymphocytes, and 7% monocytes. Serum immunoglobulin levels are IgG, 118 mg/dL; IgM, 14 mg/dL; and IgA, 23 mg/dL. The child dies of pneumonia. At autopsy, a hypoplastic thymus, small lymph nodes that lack germinal centers, and scant gut- associated lymphoid tissue are seen. Which of the following is the most likely cause of this disease?

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#9536 Environment & Nutritional Pathology

An epidemiologic study of a community shows an increased incidence of basal cell and squamous cell carcinomas in adults. These lesions are distributed predominantly on palms and soles. Analysis of groundwater pumped from wells for drinking shows increased levels of heavy metal used in pressure-treated lumber (with a greenish hue), insecticides, and herbicides. Which of the following metals is most likely implicated by this study?

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