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Pathology Practice MCQs

Browse 15,526 high-yield clinical questions in Pathology. Includes detailed explanations, options, and topic tags.

#6457 Kidney

A 63-year-old man is in stable condition after an acute myocardial infarction when he became hypotensive for 3 hours before paramedical personnel arrived. Over the next week, the serum urea nitrogen level increases to 48 mg/dL, the serum creatinine level increases to 5 mg/dL, and the urine output decrease. He undergoes hemodialysis for the next 2 weeks and then develops marked polyuria, with urine output of 2 to 3 L/day. His renal function gradually returns to normal. Release of which of the following substances most likely participated in the elevation of BUN, creatinine, and reduced urinary output?

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#6470 Neoplasia

A 65-year-old man complains of muscle weakness and a dry cough for 4 months. He has smoked two packs of cigarettes daily for 45 years. A chest X-ray shows a 4-cm central, left lung mass. Laboratory studies reveal hyperglycemia and hypertension. A transbronchial biopsy is diagnosed as small cell carcinoma. Metastases to the liver are detected by CT scan. Which of the following might account for the development of hyperglycemia and hypertension in this patient?

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#6471 Blood

A 39-year-old man has experienced chronic fatigue and weight loss for the past 3 months. There are no remarkable findings on physical examination. Laboratory studies show hemoglobin, 10.0 g/dL; hematocrit, 30.3%; MCV, 91 mm3; platelet count, 240,000/ mm3; WBC count, 7550/ mm3; serum iron 80 mg/dL; total iron-binding capacity, 145 mg/dL; and serum ferritin, 565 ng/mL. Serum erythropoietin levels are low for the level of Hb and hepcidin levels are elevated. Which of the following is the most likely diagnosis?

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#6478 Peripheral Nerve & Skeletal Muscles

A 24-year-old woman has had episodes of numbness and tingling in both hands for 5 months. The problem is worse near the end of the day and makes it difficult for her to use the computer keyboard. The thumb and first two fingers are most affected. There is no pain or swelling, and she does not recall any trauma to the upper extremities. On physical examination, she has a positive Tinel sign and decreased sensation to light touch and pinprick over the palmar surface of both hands in the distribution of the first three digits. Thenar muscle atrophy is present. This neuropathy is most likely due to which of the following underlying causes?

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#6495 General

36 year old, Jemima, is sent for mediastinoscopy with biopsy. During this procedure, a small incision is made immediately above the sternum and a rigid tube is inseed into the chest cavity for visualization of the mediastinum by video camera. Several biopsies of lymph nodes are taken and sent for pathologic examination. In these biopsies, the normal lymphoid tissue has been replaced by a mixed population of morphologically normal cells including histiocytes, lymphocytes, monocytes, plasma cells, and eosinophils. Admixed with these cells are infrequent numbers of large binucleate cells with large prominent eosinophilic nucleoli. Immunophenotyping demonstrates that these cells are positive for CD15 and CD30. The CD15 and CD30 positive cells are most likely which of the following?

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