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Pathology Practice MCQs

Browse 15,526 high-yield clinical questions in Pathology. Includes detailed explanations, options, and topic tags.

#1952 Liver & Biliary Tract

A 36-year-old, alcoholic woman presents with a 1-week history of yellow skin and sclerae. She has suffered persistent headaches. Her vital signs are normal. Physical examination reveals jaundice. Laboratory studies disclose markedly elevated levels of AST and ALT (956 and 1,400 U/L, respectively). A few days later, she develops hepatic encephalopathy and renal failure. A liver biopsy shows prominent centrilobular necrosis. Which of the following is the most likely diagnosis?

#1953 Central Nervous System

A 50-year-old woman develops a sudden, severe headache and is taken to the emergency department. On examination, she has nuchal rigidity. Her blood pressure is 115/83 mm Hg. A lumbar puncture is done; the CSF shows numerous RBCs, no neutrophils, a few mononuclear cells, and a normal glucose level. The Gram stain result is negative. CT imaging shows subarachnoid hemorrhage at the base of the brain. Which of the following vascular events has most likely occurred in this woman?

#1979 Miscellaneous

A 40-year-old woman presents with a long history of vague upper abdominal pain and frequent indigestion with abdominal tenderness. Serum bilirubin is elevated (4.2 mg/dL). There is a mild increase in serum AST and ALT (62 and 57 U/L, respectively) and a moderate increase in alkaline phosphatase (325 U/L). Markers for viral hepatitis are negative. Abdominal ultrasound examination shows echogenic stone-like material within the gallbladder and thickening of the gallbladder wall. An intrahepatic mass is also visualized adjacent to the gallbladder. A cholecystectomy is performed. Histologic examination shows dense fibrosis and glandular structures in the wall of the gallbladder. What is the most likely diagnosis?

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