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Pathology General 517defba

Major source of collagen in cirrhosis?

A
Kupfer cells
B
Ito cell (Hepatic stellate cell)
C
Hepatocyte
D
Canalicular cell
High-Yield Explanation
Ans. is 'b' i.e., Ito cell (hepatic stellate cell)Perisinusoidal stellate cells (Ito cells) play a role in the storage and metabolism of vitamin A and are transformed into collagen producing myofibroblasts when there is inflamation of the liver.These cells are the major source of collegen in cirrhosis.

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