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Pathology Practice MCQs

Browse 15,526 high-yield clinical questions in Pathology. Includes detailed explanations, options, and topic tags.

#9956 Kidney

A 20-year-old primigravid woman is in the third trimester and has felt minimal fetal movement. An ultrasound scan shows bilaterally enlarged echogenic kidneys and a markedly decreased amniotic fluid index. She gives birth to a stillborn male fetus at 33 weeks' gestation. At autopsy, there are deformations resulting from marked oligohydramnios, including flattening of the facies, varus deformities of the feet, and marked pulmonary hypoplasia. Microscopic examination of the liver shows multiple epithelium-lined cysts and proliferation of bile ducts. Which of the following is the most likely renal disease in this fetus?

#9981 Neoplasia

A 26-year-old woman has a lumps in her left breast. On physical examination, she has an irregular, firm, 2-cm mass in the upper inner quadrant of the breast. No axillary adenopathy is noted. A fine-needle aspirate of the mass shows anaplastic ductal cells. The patient's 30-year-old sister was recently diagnosed with ovarian cancer, and 3 years ago her maternal aunt was diagnosed with ductal carcinoma of the breast and had a mastectomy. Mutation involving which of the following genes is most likely present in this family?

#9990 Liver & Biliary Tract

A 66-year-old woman with a history of chronic alcohol abuse has had headaches and nausea for the past 4 days. She has become increasingly obtunded. On physical examination, she has right upper quadrant tenderness, tachycardia, tachypnea, and hypotension. Laboratory studies show serum AST of 475 U/L, ALT of 509 U/L, alkaline phosphatase of 23 U/L, total bilirubin of 0.9 mg/dL, albumin of 3.8 g/dL, and total protein of 6.1 g/dL. She is treated with N-acetylcysteine. Which of the following drugs has she most likely ingested in excess?

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