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Pathology Miscellaneous 88ef5518

All of the following statements are true for insulinoma except:

A
These are most common pancreatic endocrine neoplasms
B
Mostly are multiple
C
These are benign
D
Deposition of amyloid is characterstic
High-Yield Explanation
Insulinoma: Beta cell tumors (insulinomas) are most common pancreatic endocrine neoplasms which are benign & may produce sufficient insulin to induce clinically significant hypoglycemia. Ix - High circulating levels of insulin & High insulin-to-glucose ratio. Most often found within pancreas & are mostly solitary M/E -Looks like giant islets, with preservation of regular cords of monotonous cells Deposition of amyloid is a characteristic feature Hypoglycemic attacks -Confusion, Stupor, and Loss of consciousness. Precipitated by fasting or exercise and are promptly relieved by feeding or parenteral administration of glucose. Rx - Surgical resection.

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