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Medicine Practice MCQs

Browse 18,554 high-yield clinical questions in Medicine. Includes detailed explanations, options, and topic tags.

#3039 General

A family suffering a hereditary form of severe emphysema, with some family members also showing hepatic disease. Liver biopsy in one of the family members demonstrates increased reactivity with antibodies directed against a-1-antitrypsin. Serum levels of the enzyme are low, leading to increased activity of a number of serine proteases. Increased activity of which of the following serine proteases has been most closely tied to the emphysema that develops in these patients?

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