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Pathology General f9502422

Splenomegaly may be a feature of:March 2013

A
Megaloblastic anemia
B
Sickle cell anemia
C
Thalassemia
D
G6PD deficiency
High-Yield Explanation
Ans. B i.e. Sickle cell anemiaSplenomegalySplenomegaly refers strictly to spleen enlargement, and is distinct from hyperspineism , which connotes overactive function by a spleen of any size.Splenomegaly and hypersplenism should not be confused. Each may be found separately, or they may coexist.Clinically if a spleen is palpable, it means it is enlarged as it has to undergo enlargement by at least two folds to become palpable. However, the tip of the spleen may be palpable in a newborn baby up to 3 months of ageEarly sickle cell anemia may present with splenomegaly

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