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Pharmacology A.N.S. 65e8f2f6

Which of the following drugs increases gastro- intestinal motility?

A
Glycopyrrolate
B
Atropine
C
Neostigmine
D
Fentanyl
High-Yield Explanation
Ans. (C) Neostigmine(Ref: KDT 8th/e p130)Cholinergic drugs increase GI motility. Neostigmine is an inhibitor of the enzyme AChE (which is responsible for the breakdown of ACh). It thus acts like a cholinergic agent.Glycopyrrolate and atropine are anticholinergic drugs; thus reduce GI motility. Fentanyl is an opioid and can cause constipation.

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