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Pharmacology Cell Wall Synthesis Inhibitors f098ee27

Which of the following statements about the biodisposition of penicillins and cephalosporins is NOT accurate?

A
Oral bioavailability is affected by lability to gastric acid
B
Procaine penicillin G is used intramuscular injection
C
Renal tubular reabsorption of beta-lactams is inhibited by probenecid
D
Nafcillin and ceftriaxone are eliminated mainly biliary secretion
High-Yield Explanation
* Probenecid inhibits renal tubular secretion of penicillins (not reabsorption) * Beta lactams eliminated by biliary route are: -- Ampicillin -- Nafcillin -- Ceftriaxone -- Cefoperazone * Penicillin G has to be given by i.m. route because it is broken down by gastric acid (decreases oral bioavailability).

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