Which of the following causes hemolytic anemia -a) Hereditary spherocytosisb) Infectionc) Iron deficiencyd) Sickle cell anemiae) Copper deficiency

Hemolytic anemia may be of two types.  Intracorpuuscular Underlying cause of hemolysis is intrinsic to RBC, e.g., Defect in membrane cytoskeleton → Hereditary spherocytosis Defect in red cell enzyme → G6PD deficiency. Disorder of hemoglobin synthesis  Deficient globin synthesis →Thalassemia Structurally abnormal globin → Sickle cell anaemia. (hemoglobinopathies) Membrane defect → Paroxysmal nocturnal hemoglobinuria                     2. Extracorpuscular Underlying cause of hemolysis is extrinsic, ie., not within RBC, e.g., : - Immunohemolytic anemia Microangiopathic hemolytic anemia → (i) TTP,  (ii) HUS,  (iii) DIC Infection → Malaria Mechanical trauma to RBC → rosthetic valve. Hyperspienism