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Medicine Miscellaneous ebc41bdd

All of the following changes in liver are seen in Wilson's disease, EXCEPT

A
Cirrhosis
B
Fatty liver
C
Acute hepatitis
D
Fulminant hepatitis
High-Yield Explanation
(B) Fatty liver # Hepatic> Wilson's disease may present as hepatitis, cirrhosis, or as hepatic decompensation, typically in the mid- to late-teenage years in western countries, although the age of presentation is quite broad and extends into the fourth decade of life.> In India and countries in the Far East, the hepatic presentation may occur much earlier, often in children only five or six years of age.> An episode of hepatitis may occur, with elevated blood transaminase enzymes, with or without jaundice, and then spontaneously regress.> Hepatitis often reoccurs, and most of these patients eventually develop cirrhosis.> Hepatic decompensation is associated with elevated serum bilirubin, reduced serum albumin and coagulation factors, ascites, peripheral edema, and hepatic encephalopathy.> In severe hepatic failure, hemolytic anemia may occur because large amounts of copper are released into the bloodstream> The association of hemolysis and liver disease makes Wilson disease a likely diagnosis.

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