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Pharmacology Chemotherapy: General Principles e9403265

All of the following anticancer drugs act on G2 phase except:

A
Paclitaxel
B
Etoposide
C
Irinotecan
D
Bleomycin
High-Yield Explanation
Ans. (A) Paclitaxel(Ref: Katzung 13th/e p921)Paclitaxel is a taxane that act on mitotic spindle. Drugs acting on mitotic spindle act on M phase of cell cycle.Phase of cell cycleDrugs actingG1EtoposideSAntimetabolitesG2BleomycinEtoposideIrinoctecanTopotecanMVinca alkaloidsTaxanes

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