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Pathology JIPMER 2017 bbb39352

Dohle like inclusions in neutrophils along with giant platelets is characteristic of:

A
Bernard Soulier syndrome
B
Chediak Higashi syndrome
C
May Hegglin anomaly
D
Pelger Huet anomaly
High-Yield Explanation
May-Hegglin anomaly (MHA) Autosomal dominant disorder Thrombocytopenia associated with purpura and bleeding Giant platelets containing few granules Large, well-defined, basophilic, cytoplasmic inclusion bodies in granulocytes that resemble Dohle bodies. Dohle bodies are single or multiple blue cytoplasmic inclusions that are remnants of rough endoplasmic reticulum.

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