Mutation of which of the following gene is most impoant in paroxysmal nocturnal hemaglobinuria?
High-Yield Explanation
Ans. is 'c Glycosyl phosphatidylinositol o PNH results from acquired mutation that inhibits the synthesis of Glycosyl-phosphatidyl-inositol (GPI). o The GPI linked proteins that are missing are membrane inhibitors of reactive lysis (MIRL; CD59), delay accelerating factor (DAF; CD55), C8 binding protein, urokinase plasminogen activator receptor, leukocyte alkaline phosphatase (LAP).