A characteristic pathological feature of Parkinson's disease is presence of -

Pathologic Examination in Parkinson shows : Gross / Macroscopically: Pallor of the substantia nigra and locus coeruleus Microscopic Examination :     1. Loss of catecholaminergic neurons in these regions + gliosis 2. Lewy bodies. Lewy bodies: are inclusion bodies found within neurons in Parkinson's disease. Lewy bodies are single or multiple, intra-cytoplasmic, eosinophilic, round and elongated inclusions that often have a dense core surrounded by a pale halo. Ultrastructurally: These are composed of fine filaments, densely packed in the core but loose at the rim.