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Pharmacology General cf9594c0

Which of the following anticancer drug is excreted by lungs ?

A
5–Fluorouracil
B
Cyclophosphamide
C
Doxorubicin
D
Cisplatin
High-Yield Explanation
5-Fluorouracil is rapidly metabolized in liver to produce biologically inactive metabolites which are eventually con­verted to carbon dioxide and eliminated by lungs. Excretion of 80% of 5-FU can be accounted for by conversion to carbon dioxide within 12 hour of administration though its excretion in urine is only 15%. Also note other drugs excreted by lungs are procainamide, procaine and antipyrine.

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