'Knudson's two-hit' hypothesis is associated with

Harshmohan textbook of pathology 7th edition. ☆ Familial retinoblastoma comprises 40% of cases and may be bilateral. In this cases, all somatic cells inherit one mutant RB gene from a carrier parent. Later during life, the other mutational event of 2nd allele affecting the somatic cells occurs. This forms the basis of two hot hypothesis given by Knudson in 1971.