Most common cause of moebius syndrome in use of which of the following drug in pregnancy

Moebius syndrome is extremely rare congenital condition characterized by facial paralysis and inability to move the laterally. It results due to paralysis of 6th and 7th cranial nerves impoant causes of this syndrome are Bih trauma Use of misoprostal in mother during pregnancy Use of thalidomide in mother during pregnancy Use of cocaine in mother during pregnancy Refer katzung 11/e p1029