A 15-year-old boy presented with one day history of bleedig gums, subconjunctival bleed and purpuric rash. Investigations revealed the following results:Hb-6.4 gm/dL; TLC-26,500/mm3 Platelet 35,000 mm3; prothrombin time-20 sec with a control of 13 sec; partial thromboplastin time-50sec; and Fibrinogen 10ing/dL. Peripheral smear was suggestive off acute myeloblastic leukemia. Which of the following is the most likely -

The child presents with acute onset of bleeding, along with the following laboratory anamolies. Thrombocytopenia    (iii) Increased partial thromboplastin time. Increased prothrombin time    (iv) Decreased Fibrinogen These hematological abnormalities indicate Disseminated intravascular coagulation The peripheral blood smear of the patient is suggestive of acute myeloblastic leukemia (mentioned in the question) The AML most likely to occur in this setting is promyelocytic leukemia as it is the most common myeloid leukemia associated with DIC. Promyelocytic (AML-M3) leukemic promyelocytes liberate tissue thromboplastin leading to disseminated intravascular coagulation.