Pharmacology A.N.S. a85ab24a

Neostigmine is not able to cross blood brain barrier because of its:

Primary structure

Secondary structrure

Tertiary structure

Quarternary structure

High-Yield Explanation

Ans. (D) Quarternary structure(Ref: KDT 8th/e p116)Quarternary ammonium compounds are water soluble and thus cannot cross blood brain barrier. Neostigmine is a quarternary derivative whereas physostigmine is a tertiary amine.

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Neostigmine is not able to cross blood brain barrier because of its:

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