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Medicine General a507440b

Virilisation of the female is present in all, EXCEPT

A
17-α hydroxylase deficiency
B
21-α hydroxylase deficiency
C
11-α hydroxylase deficiency
D
11-α hydroxysteroid deficiency
High-Yield Explanation
Congenital adrenal hyperplasia - Is commonly caused by following 3 enzyme deficiencies 21 α hydroxylase deficiency (complete) 21 α hydroxylase deficiency (partial) 11 α Hydroxylase deficiency 17 α hydroxylase deficiency 17 α hydroxylase deficiency Hypertension No virilization in females (because the gene that codes for 17 α also codes for the enzyme in adrenal cortex). Primary amenorrhoea and failure of development of secondary sexual characteristic in females. Male pseudohermaphrodites 21 α hydroxylase deficiency Complete (Salt losing virilizing syndrome) Hypotension Virilization (& Precocious puberty in males) 21α hydroxylase deficiency Partial (Simple virilizing) Normal B.P. Virilization (& Precocious puberty in males) 11 β hydroxylase deficiency Hypertension Virilization (& Precicous puberty in males)

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