To which of the following cell types do 'hea-failure' cells belong?
High-Yield Explanation
Left-sided hea failure leads to pulmonary congestion and edema. There is extravasation of red cells and plasma proteins in the alveoli which are phagocytosed and digested by macrophages The accumulated iron from ingested red cells is stored as hemosiderin. These hemosiderin-laden macrophages are also known as hea failure cells and are telltale signs of previous episodes of pulmonary edema. The common causes of left-sided cardiac failure Ischemic hea disease (IHD) Systemic hypeension Mitral or aoic valve disease Primary diseases of the myocardium (e.g., amyloidosis)