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Pathology General 84aad0a7

Which of the following statements about Rheumatoid Factor is true -

A
It is an IgM antibody directed against IgG
B
It is an IgG antibody directed against IgM
C
It is more specific than Anti-CCP antibodies
D
It is positive in all cases of Juvenile Rheumatoid Arthritis
High-Yield Explanation
Rheumatoid factor in Rheumatoid Arthritis is an IgM antibody directed against the Fc fragment of IgG Anti CCP antibodies are most specific blood test for rheumatoid arthritis (specificity ∼ 95%). Rheumatoid factor is positive in only 10% of patients with JRA.
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