IN activated protien C resistent disorder due to inactivation ?

Factor V Leiden mutation * Factor V Leiden is an autosomal dominant condition that exhibits incomplete dominance and results in a factor V variant that cannot be as easily degraded by activated Protein C. * The gene that codes the protein is referred to as F5. Mutation of this gene is a single nucleotide polymorphism located on chromosome 1 in exon 10 * As a missense substitution it changes a protein&;s amino acid from arginine to glutamine. ref : robbins 10th ed