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Physiology General 7175118a

JAK-STAT kinase receptors is associated with ?

A
T cAMP
B
IP3 - DAG
C
Ion channels
D
Nuclear transcription
High-Yield Explanation
Ans. is'd'i.e., Nuclear transcriptionJAK-STAT-Kinase binding receptors:These receptors differ in not having intracellular enzymatic action on receptor itself. Agonist binding induces interaction of these receptors with free intracellular tyrosine kinase - Janus kinase (JAK).jAK phosphorylates activators of transcription (STAT), which then regulate the nucleus transcription resulting in a biological response.Examples -+ Growth hormone, Prolactin,

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