In Alzheimer’s disease, plaque is made up of:

(Refer: Robbins Pathologic Basis of Disease, 8thedition, pg no: 1313-1317) Morphology of Alzheimer's disease Cortical atrophy especially in frontal, temporal and parietallobes. Compensatory ventricular enlargement due to loss ofparenchyma and reduced brain volume - (hydrocephalus exvacuo). Structures involved early - medial temporal lobe, including hippocampus entorhinal cortex and amygdala. Progressive severe neuronal loss and reactive gliosis