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Gynaecology & Obstetrics Sex Intersexuality 62b98291

Most common cause of ambiguous genitalia in a female child is:

A
Placenta steroid sulfatase deficiency
B
Fetal aromatase deficiency
C
Wnt4 mutation
D
Congenital adrenal hyperplasia
High-Yield Explanation
Ans. is d, i.e. Congenital adrenal hyperplasiaRef Leon Speroff 8 th/ed, p349; Dutta Gyne 6th/ed, p440"CAH due to 21 hydroxylase deficiency is the most frequent cause of sexual ambiguity and the M/C endocrine cause of neonatal death." - Ref: Leon Speroff 8th/ed, p349Ambiguity of sex at birth -- "Cases of ambiguity of sex detected at birth are due to adrenogenital syndrome unless proved otherwise". - Ref: Dutta Gynae 6th/ed, p404

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