Paul Bunnell antibodies are reactive in all except:

Ans. is 'a' i.e., Ox(Ref: Ananthanarayan, 9th/e, p. 109, 476 and 8th/e, p. 108, 477; Harrison, 18th/e, p. 1469, 1470; 19th/e, p. 1189)* In infectious mononucleosis, Paul Bunnel heterophile antibodies are produced.* These IgM class antibodies have an affinity for sheep, horse and bovine erythrocyte and a titre of >40 is diagnostic of acute EBV infection.* Because these heterophile antibodies are adsorbed by ox red cells, they are not reactive in Ox (Ox red cells remove these antibodies).* Monospot test is more sensitive and specific than Paul Bunnel test.* EBV specific antibody testing is used for patients, Titers of IgM and IgG abs to Viral capsid antigen (VCA) are elevated in 90% of patients at the onset of disease.* Abs against EBNA are also demonstrated. EA - D abs are found in severe disease by EBV.* Nowadays EBV DNA are demonstrated by PCR.