A 15-year-old boy presented with 1 day history of bleeding gums, subconjunctival bleed and purpuric rash. Investigations revealed: Hb 6.4 gm/dl; TLC-26,500/mm3; prothrombin time-20 sec with a control of 13 sec; paial thromboplastin time-50 sec; and fibrinogen 10 mg/dl. Peripheral smear was suggestive of acute myeloblastic leukemia. Which of the following is the most likely?
High-Yield Explanation
- This patient has complaints of bleeding along with thrombocytopenia, decreased fibrinogen & increased PT & APTT. - These features are consistent with DIC. - DIC is most commonly associated with M3 subtype of AML= APML