Migratory thrombophlebitis is caused by

Carcinomas of the pancreas typically remain silent until theirextension impinges on some other structure. Pain usually is thefirst symptom, but by that point these cancers are oftenbeyond cure. Obstructive jaundice can be associated withcarcinoma in the head of the pancreas, but it rarely drawsattention to the cancer soon enough for timely intervention.Weight loss, anorexia, and generalized malaise and weaknessare manifestations of advanced disease. Migratory thrombophlebitis (Trousseau syndrome) occurs in about 10% of patients and is attributable to the elaboration of platelet aggregating factors and pro-coagulants from the tumor or its necrotic products.Robbins Basic pathology, 9th edition, pg no.654