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Gynaecology & Obstetrics General 211a7500

Which of the following is seen in the ovulatory phase?

A
Stimulation of continuation of reduction division of oocytes
B
Inhibin A is increased
C
FSH increases steroid synthesis in granulosa cells
D
Activin causes FSH to act on granulosa cells
High-Yield Explanation
Let's analyse each option - In the ovulatory phase. Option a: Stimulation of continuation of reduction division of oocytes - correct During oogenesis, the primary oocyte is arrested in prophase of meiosis Just before ovulation, the LH surge initiates the continuation of meiosis, forming secondary oocyte and 1st polar body. "Die LH surge initiates the resumption of meiosis in the oocyte (meiosis is not completed until after the sperm has entered and second polar body is released." — Leon speroff 8th/ed p 229 Option b: Inhibin A is increased in ovulatory phase - incorrect Levels of inhibin A are increased and reach a peak in the midluteal phase, not in the ovulatory phase. Option c: FSH increases steroid synthesis in granulosa cells — incorrect FSH acts on the granulosa cells to produce estrogen mainly in the follicular phase and not in the ovulatory phase. Option d: Activin causes FSH to act on the granulose cells — incorrect As discussed, activin does augment the action of FSH on granulosa cells but during the early follicular phase and not during the ovulatory phase. "In the granulosa of the early follicular phase, activin augments FSH activities: FSH receptor expression, aromatization, inhibin/ activin production, and LH receptor expression. In the theca, activin suppresses androgen production, allowing the emergence of an estrogen microenvironment." — Leon speroff 8th/ed p 226.

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