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Pathology General 1f0cb5c3

Clinical feature of minimal change glomerulonephritis are all except-

A
Hypeension
B
Edema
C
Selective proteinuria
D
Fever
High-Yield Explanation
Ans. is 'a' i.e., HypeensionMinimal change diseaseo Minimal Change Disease is the most common cause of Nephrotic syndrome in children.o Edema and Selective proteinuria are features of nephrotic syndrome. Fever may be present on account of increased susceptibility to infection.o Minimal change disease prsents with insidious onset of nephrotic syndrome in children below 6 years of age.o Hypeension is not a feature of nephrotic syndrome and is rare in Minimal change disease. Hematuria (a finding of nephritic syndrome) is also rare.o Pathological findings include1. Light microscopy --> No abnormality2. Electron microscopy --> Obliteration (loss) and fusion offoot processes of epithelial cells.3. Immunofluorescence ----> No deposits of immune reactants4. Serum complements --> Normal levels o Minimal change disease has very good prognosis with excellent response to steroids.

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