Nodular regenerating hyperplasia is associated with -

Nodular regenerative hyperplasia of the liver This is the most common cause of non-cirrhotic poal hypeension in developed countries; it is characterised by small hepatocyte nodules throughout the liver without fibrosis, which can result in sinusoidal compression. It is believed to be due to damage to small hepatic aerioles and poal venules. It occurs in older people and is associated with many conditions, including connective tissue disease, haematological diseases and immunosuppressive drugs, such as azathioprine. The condition is usually asymptomatic but occasionally presents with poal hypeension or with an abdominal mass. The diagnosis is made by liver biopsy, which, in contrast to cirrhosis, shows nodule formation in the absence of fibrous septa. Liver function is good and the prognosis is very ourable. Management is based on treatment of the poal hypeension. Ref Davidson edition23rd pg899