The term “end-stage renal disease (ESRD)” is considered appropriate when GFR falls to

• Most children with GFR >30% of normal are asymptomatic. • Reduction of GFR below 25—30 mL/min/1.73 m2 is associated with symptoms. • End-stage renal disease (ESRD)—GFR of 5—10 mL/min/ 1.73 m2, characterized by decline of renal function to a degree when life cannot be sustained without chronic dialysis or transplantation.