Pharmacology General ff420dae Which of the following thiazide can be used in severe renal failure? A Chlorthiazide B Metolazone C Trichloromethazide D Bendroflumethiazide High-Yield Explanation Thiazide diuretics can't be used in severe renal failure cases as they alter GFR. But Metolazone and Indapamide are the exceptions.