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Surgery General ff223aa2

University of Wisconsin solution is used in:

A
Organ preservation
B
Virus isolation
C
Gene therapy
D
All of the above
High-Yield Explanation
The most commonly used fluid worldwide is the University of Wisconsin solution. It contains lactobionate, raffinose, and hydroxyethyl starch. Lactobionate is impermeable and prevents intracellular swelling; it also lowers the concentration of intracellular calcineurin and free iron, which may be beneficial in reducing reperfusion injury. Hydroxyethyl starch, a synthetic colloid, may help decrease hypothermia-induced cell swelling of endothelial cells and reduce interstitial edema. Another solution that is now being used commonly is histidine-tryptophan-ketoglutarate solution Ref: Schwaz's principle of surgery 9th edition, chapter 11.

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