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Pathology Hemoglobinopathies: Sickle cell anemia ff0cd1ec

Decreased osmotic fragility is not seen in which of the following conditions?

A
Thalassemia
B
Hereditary spherocytosis
C
Sickle cell anemia
D
Iron deficiency
High-Yield Explanation
- Hereditary spherocytosis is associated with increased osmotic fragility because RBCs are spherical & unstable d/t defect in their cytoskeleton. Osmotic fragility curves of normal and hereditary spherocytosis red blood cells.

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