Pediatrics Nephritic & Nephrotic Syndrome fdd7c2b2

Characteristic feature of Goodpasture's syndrome?

Lumpy-bumpy deposits on immunofluorescence

Serum antibodies against alpha 3 NC 1 domain of collagen-IV

Serum antibodies against alpha 1 NC 1 domain of collagen III

Anti DNAse antibodies positive

High-Yield Explanation

In Goodpasture syndrome, type 1 RPGN & type II hypersensitivity reaction are seen. It is characterized by serum antibodies against alpha 3 NC1 domain of collagen - IV. Lumpy-bumpy deposits on immunofluorescence- seen in Post Streptococcal GN

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Characteristic feature of Goodpasture's syndrome?

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