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Pharmacology Cardiovascular system fd09e0ce

Which of the following drug is associated with the highest cardiac moality?

A
Rofecoxib
B
Nicorandil
C
Losaan
D
Metoprolol
High-Yield Explanation
Coxibs are selective cox2 inhibitors- Basically, Coxibs are NSAIDS They won't cause gastric acidity as they won't exe their effect on cox-1 but as there is an increased chance of cardiac events like hea attack due to excess thrombosis Excess thrombosis is due to decrease in PGI2 and enhanced TXA2 Ref: KD Tripathi 8th ed.

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