Full 2L QBank
Surgery General fca49314

Which of the following childhood tumor is used N-myc gene amplification for its prognosis?

A
Neuroblastoma
B
Retinoblastoma
C
William's tumor
D
Nephroblastoma
High-Yield Explanation
Neuroblastoma is the third most common pediatric malignancy and the peak incidence is 2 years of age. Neuroblastomas arise from the neural crest cells and it originates most frequently in the adrenal glands, posterior mediastinum, neck, or pelvis but can arise in any sympathetic ganglion. The clinical presentation depends on the site of the primary and the presence of metastases. The presence of hyperdiploid tumor DNA is associated with a orable prognosis, whereas N-myc amplification is associated with a poor prognosis regardless of patient age. Ref: Hackam D.J., Grikscheit T.C., Wang K.S., Newman K.D., Ford H.R. (2010). Chapter 39. Pediatric Surgery. In F.C. Brunicardi, D.K. Andersen, T.R. Billiar, D.L. Dunn, J.G. Hunter, J.B. Matthews, R.E. Pollock (Eds), Schwaz's Principles of Surgery, 9e.

Related Surgery MCQs

Practice 2,00,000+ NEET PG Questions Free

Timed mock tests, mistake queue analytics, audio lectures & zero attempt limits on i❤️Exams.

Start Free Mock Test Now