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Medicine General fc0205ef

SIADH is associated with which of the following drug?

A
Vincristine
B
Erythromycin
C
5-FU
D
Methotrexate
High-Yield Explanation
Treatment with vincristine is known to cause SIADH. Erythromycin, 5-FU and Methotrexate are not established causes of Syndrome of Inappropriate Antidiuretic Hormone hypersecretion (SIADH). Ref: Harrison's Principles of Internal Medicine, 16th Edition, Page 2102; Drug-Induced Diseases: Prevention, Detection, and Management, 2nd Edition, James E. Tisdale, Chapter 45, Page 887.

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