Full 2L QBank
Pharmacology Cardiovascular system fbe48794

The positive inotropic effect of digitalis due to inhibition of the Na+/K+ ATPase pump in cardiac muscle cell membrane leads to:

A
Decreased activity of Na+/Ca++ exchanger causing decreased influx of sodium and decreased efflux of Ca++ in the sarcolemma
B
Decreased efflux of Na+ leading to less negative resting membrane potential and opening of voltage gated Ca++ channels on the T tubules
C
Increased intracellular Na+ causing increased efflux of Na+ and increased influx of Ca++ through Na+/ Ca++ exchanger in the sarcolemma
D
Increased intracellular Na+ decreasing the activity of Ca++ pump in the sarcoplasmic reticulum
High-Yield Explanation
Digitalis selectively binds to the extracellular face of membrane- Na-k ATPase is inhibited. Inhibition of this cation pump results in progressive accumulation of Na intracellularly. Indirectly result in intracellular Calcium accumulation. REF.Essentials of medical pharmacology K D TRIPATHI 6 Edition)
← Previous Question Next Question →

Related Pharmacology MCQs

Which of the following is glucocoicoid synthesis inhibitor?
General
At a high altitude of 3000 m, a person complains of breathlessness. All of the following can...
General
All of the following drugs act on cell membrane except:
General
A non-competitive inhibitor of an enzyme?
General
Which of the following is a phase I metabolic reaction?
General
Explore All Pharmacology Questions →

Practice 2,00,000+ NEET PG Questions Free

Timed mock tests, mistake queue analytics, audio lectures & zero attempt limits on i❤️Exams.

Start Free Mock Test Now