Substrate controlled hormone is:

Blood glucose and amino acids are the substrates for glucagon. The levels of these substrates control the glucagon secretion. Glucagon secretion is stimulated by: Hypoglycemia, increase amino acids, stress, exercise, sympathetic stimulation Glucagon secretion is inhibited by: Insulin, increase blood glucose, somatostatin. Hypoglycemia is the most impoant stimulus. Protein rich meal and serum amino acids stimulate glucagon and insulin secretion. Arginine stimulates both glucagon and insulin secretion; alanine stimulates only glucagon secretion directly.